Cargando…

CRANAD-28: A Robust Fluorescent Compound for Visualization of Amyloid Beta Plaques

CRANAD-28, a difluoroboron curcumin analogue, has been demonstrated in earlier reports to successfully label amyloid beta (Aβ) plaques for imaging both ex vivo and in vivo. CRANAD-28’s imaging brightness, ability to penetrate the blood brain barrier, and low toxicity make the compound a potentially...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ran, Kathleen, Yang, Jing, Nair, Anil V., Zhu, Biyue, Ran, Chongzhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070309/ https://www.ncbi.nlm.nih.gov/pubmed/32079064 http://dx.doi.org/10.3390/molecules25040863

Ejemplares similares

In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice
por: Ni, Ruiqing, et al.
Publicado: (2021)

Differentiating Aβ40 and Aβ42 in amyloid plaques with a small molecule fluorescence probe
por: Yang, Jing, et al.
Publicado: (2020)

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
por: Yang, Jing, et al.
Publicado: (2020)

Degradation of amyloid beta species by multi-copper oxidases
por: Yang, Jing, et al.
Publicado: (2023)

The Application of Bio-orthogonality for In Vivo Animal Imaging
por: Yang, Jun, et al.
Publicado: (2023)

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species
por: Ran, Chongzhao, et al.
Publicado: (2011)

Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species
por: Li, Yuyan, et al.
Publicado: (2017)

The double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants
por: Yang, Jing, et al.
Publicado: (2017)

Green-Fluorescent Protein(+) Astrocytes Attach to Beta-Amyloid Plaques in an Alzheimer Mouse Model and Are Sensitive for Clasmatodendrosis
por: Daschil, Nina, et al.
Publicado: (2016)

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?
por: Humpel, Christian
Publicado: (2022)

Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain
por: Richards, Danielle, et al.
Publicado: (2014)

Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease
por: Luo, Ziyi, et al.
Publicado: (2021)

Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation
por: Hajdú, István, et al.
Publicado: (2023)

Microglia use TAM receptors to detect and engulf amyloid beta plaques
por: Huang, Youtong, et al.
Publicado: (2021)

Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease
por: Tong, Hongjuan, et al.
Publicado: (2015)

Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo
por: Chen, Yi
Publicado: (2023)

A Highly Selective Turn-on Fluorescent Probe for the Detection of Aluminum and Its Application to Bio-Imaging
por: Wang, Liguo, et al.
Publicado: (2019)

The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review
por: Brand, Abby L., et al.
Publicado: (2022)

Intermediate antiparallel beta structure in amyloid plaques revealed by infrared spectroscopic imaging
por: Holcombe, Brooke, et al.
Publicado: (2023)

Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET
por: Therriault, Joseph, et al.
Publicado: (2023)

The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy
por: Johansson, Björn, et al.
Publicado: (2023)

In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimer’s Disease Models
por: Zhang, Jing, et al.
Publicado: (2023)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
por: Hashimoto, Tadafumi, et al.
Publicado: (2020)

Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice
por: Hayes, Crystal D., et al.
Publicado: (2012)

Positron emission tomography imaging of amyloid-beta plaque deposition: a decade of translation
por: Price, Julie C, et al.
Publicado: (2012)

Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
por: Lam, Suzanne, et al.
Publicado: (2022)

A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques
por: Heo, Cheol Ho, et al.
Publicado: (2016)

Fluorescence-Labeled Amyloid Beta Monomer: A Molecular Dynamical Study
por: Gera, János, et al.
Publicado: (2020)

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls
por: Esparza, Thomas J., et al.
Publicado: (2018)

Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer's disease brains
por: Palombo, Francesca, et al.
Publicado: (2018)

Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation
por: Yang, Jing, et al.
Publicado: (2018)

Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity
por: Collins-Praino, Lyndsey E, et al.
Publicado: (2014)

Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease
por: Madrasi, Kumpal, et al.
Publicado: (2021)

Naringin Chelates Excessive Iron and Prevents the Formation of Amyloid-Beta Plaques in the Hippocampus of Iron-Overloaded Mice
por: Jahanshahi, Mehrdad, et al.
Publicado: (2021)

Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28
por: Chen, Li-Mei, et al.
Publicado: (2019)

Integration of Fluorescence Detection and Image-Based Automated Counting Increases Speed, Sensitivity, and Robustness of Plaque Assays
por: Masci, Allyson L., et al.
Publicado: (2019)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model
por: Humpel, Christian
Publicado: (2021)

Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain
por: Santhosh Kumar, Harshitha, et al.
Publicado: (2023)

Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: a representative case study
por: Liu, Biyue, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cptkhihkkt1n03ckea1at171v3