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Synthesis of Natural (−)-Antrocin and Its Enantiomer via Stereoselective Aldol Reaction

The total synthesis of (−)-antrocin and its enantiomer are presented. Antrocin (−)-1 is an important natural product which acts as an antiproliferative agent in a metastatic breast cancer cell line (IC(50): 0.6 μM). The key features of this synthesis are: (a) selective anti-addition of trimethylsily...

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Detalles Bibliográficos
Autores principales: Angamuthu, Venkatachalam, Tai, Dar-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070359/
https://www.ncbi.nlm.nih.gov/pubmed/32075004
http://dx.doi.org/10.3390/molecules25040831