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Synthesis of Natural (−)-Antrocin and Its Enantiomer via Stereoselective Aldol Reaction
The total synthesis of (−)-antrocin and its enantiomer are presented. Antrocin (−)-1 is an important natural product which acts as an antiproliferative agent in a metastatic breast cancer cell line (IC(50): 0.6 μM). The key features of this synthesis are: (a) selective anti-addition of trimethylsily...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070359/ https://www.ncbi.nlm.nih.gov/pubmed/32075004 http://dx.doi.org/10.3390/molecules25040831 |