Cargando…

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past. To obtain new molecules potentially able to act on different targets involved in inflammation onset we designed and sy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brullo, Chiara, Massa, Matteo, Rapetti, Federica, Alfei, Silvana, Bertolotto, Maria B., Montecucco, Fabrizio, Signorello, Maria Grazia, Bruno, Olga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070443/ https://www.ncbi.nlm.nih.gov/pubmed/32085423 http://dx.doi.org/10.3390/molecules25040899

Ejemplares similares

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
por: Signorello, Maria Grazia, et al.
Publicado: (2021)

Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative
por: Alfei, Silvana, et al.
Publicado: (2021)

Microbiological Screening of 5-Functionalized Pyrazoles for the Future Development of Optimized Pyrazole-Based Delivery Systems
por: Brullo, Chiara, et al.
Publicado: (2022)

Synthesis and Characterization of Pyrazole-Enriched Cationic Nanoparticles as New Promising Antibacterial Agent by Mutual Cooperation
por: Alfei, Silvana, et al.
Publicado: (2022)

Enhanced Antibacterial Activity of a Cationic Macromolecule by Its Complexation with a Weakly Active Pyrazole Derivative
por: Schito, Anna Maria, et al.
Publicado: (2022)

Inside the Mechanism of Action of Three Pyrazole Derivatives in Human Platelets and Endothelial Cells
por: Brullo, Chiara, et al.
Publicado: (2023)

Pyrazole-Enriched Cationic Nanoparticles Induced Early- and Late-Stage Apoptosis in Neuroblastoma Cells at Sub-Micromolar Concentrations
por: Zuccari, Guendalina, et al.
Publicado: (2023)

Hydrogel Formulations of Antibacterial Pyrazoles Using a Synthesized Polystyrene-Based Cationic Resin as a Gelling Agent
por: Alfei, Silvana, et al.
Publicado: (2023)

Pyrazole-Based Water-Soluble Dendrimer Nanoparticles as a Potential New Agent against Staphylococci
por: Alfei, Silvana, et al.
Publicado: (2021)

Reshaped as polyester-based nanoparticles, gallic acid inhibits platelet aggregation, reactive oxygen species production and multi-resistant Gram-positive bacteria with an efficiency never obtained
por: Alfei, Silvana, et al.
Publicado: (2019)

Antiproliferative Imidazo-Pyrazole-Based Hydrogel: A Promising Approach for the Development of New Treatments for PLX-Resistant Melanoma
por: Alfei, Silvana, et al.
Publicado: (2023)

Imidazo-Pyrazole-Loaded Palmitic Acid and Polystyrene-Based Nanoparticles: Synthesis, Characterization and Antiproliferative Activity on Chemo-Resistant Human Neuroblastoma Cells
por: Valenti, Giulia Elda, et al.
Publicado: (2023)

Synthesis, Characterization of Chitosan-Aluminum Oxide Nanocomposite for Green Synthesis of Annulated Imidazopyrazol Thione Derivatives
por: Abdel-Naby, Abir S., et al.
Publicado: (2021)

Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable
por: Alfei, Silvana, et al.
Publicado: (2022)

Amino-Pyrazoles in Medicinal Chemistry: A Review
por: Lusardi, Matteo, et al.
Publicado: (2023)

New perspectives for natural antimicrobial peptides: application as antinflammatory drugs in a murine model
por: Capparelli, Rosanna, et al.
Publicado: (2012)

Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry
por: Brullo, Chiara, et al.
Publicado: (2020)

Potent and Broad-Spectrum Bactericidal Activity of a Nanotechnologically Manipulated Novel Pyrazole
por: Alfei, Silvana, et al.
Publicado: (2022)

Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice
por: Recinella, Lucia, et al.
Publicado: (2020)

MON-478 Antinflammatory and Antioxidant Effects of MIA-690 and MR-409 in GHRHKO Mice Colon and Prefrontal Cortex
por: Leone, Sheila, et al.
Publicado: (2019)

Publisher Correction: Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice
por: Recinella, Lucia, et al.
Publicado: (2020)

Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode
por: Burke, Adam, et al.
Publicado: (2023)

Timely Recognition and Early Multi-Step Antinflammatory Therapy May Prevent ICU Admission of Patients With MIS-C: Proposal for a Severity Score
por: Brisca, Giacomo, et al.
Publicado: (2021)

Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids
por: Amado, Patrícia S. M., et al.
Publicado: (2022)

Oxaprozin-Induced Apoptosis on CD40 Ligand-Treated Human Primary Monocytes Is Associated with the Modulation of Defined Intracellular Pathways
por: Montecucco, Fabrizio, et al.
Publicado: (2009)

From Nanobiotechnology, Positively Charged Biomimetic Dendrimers as Novel Antibacterial Agents: A Review
por: Alfei, Silvana, et al.
Publicado: (2020)

Positively Charged Polymers as Promising Devices against Multidrug Resistant Gram-Negative Bacteria: A Review
por: Alfei, Silvana, et al.
Publicado: (2020)

Antibacterial Activity of Non-Cytotoxic, Amino Acid-Modified Polycationic Dendrimers against Pseudomonas aeruginosa and Other Non-Fermenting Gram-Negative Bacteria
por: Schito, Anna Maria, et al.
Publicado: (2020)

β-Lactam Antibiotics and β-Lactamase Enzymes Inhibitors, Part 2: Our Limited Resources
por: Alfei, Silvana, et al.
Publicado: (2022)

Asymmetric Organocatalytic Mannich Reaction in the Synthesis of Hybrid Isoindolinone-Pyrazole and Isoindolinone-Aminal from Functionalized α-Amidosulfone
por: Di Mola, Antonia, et al.
Publicado: (2023)

Cationic Materials for Gene Therapy: A Look Back to the Birth and Development of 2,2-Bis-(hydroxymethyl)Propanoic Acid-Based Dendrimer Scaffolds
por: Alfei, Silvana
Publicado: (2023)

Considerable Improvement of Ursolic Acid Water Solubility by Its Encapsulation in Dendrimer Nanoparticles: Design, Synthesis and Physicochemical Characterization
por: Alfei, Silvana, et al.
Publicado: (2021)

Nanotechnological Manipulation of Nutraceuticals and Phytochemicals for Healthy Purposes: Established Advantages vs. Still Undefined Risks
por: Alfei, Silvana, et al.
Publicado: (2021)

Lectin-induced oxidative stress in human platelets
por: Signorello, Maria Grazia, et al.
Publicado: (2020)

Platelet Metabolic Flexibility: A Matter of Substrate and Location
por: Ravera, Silvia, et al.
Publicado: (2023)

Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping
por: Murineddu, Gabriele, et al.
Publicado: (2012)

Synthesis and Antibacterial Activity of Cationic Amino Acid-Conjugated Dendrimers Loaded with a Mixture of Two Triterpenoid Acids
por: Schito, Anna Maria, et al.
Publicado: (2021)

Synthetic Pathways to Non-Psychotropic Phytocannabinoids as Promising Molecules to Develop Novel Antibiotics: A Review
por: Alfei, Silvana, et al.
Publicado: (2023)

Recommendations to Synthetize Old and New β-Lactamases Inhibitors: A Review to Encourage Further Production
por: Alfei, Silvana, et al.
Publicado: (2022)

One-Step, Low-Cost, Operator-Friendly, and Scalable Procedure to Synthetize Highly Pure N-(4-ethoxyphenyl)-retinamide in Quantitative Yield without Purification Work-Up
por: Alfei, Silvana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vcj90opl364sifnmjfbma8ojo6