Synthesis of the Novel Covalent Cysteine Proteases Inhibitor with Iodoacetic Functional Group

This work presents the synthesis of the novel covalent inhibitor of cysteine proteases where epoxide has been replaced by the iodoacetyl functional group. The molecule, similar in action to E-64 and DCG-04, the commonly applied inhibitors, is additionally biotinylated and contains tyrosyl iodination...

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Detalles Bibliográficos
Autores principales: Hartman, Kinga, Mielczarek, Przemyslaw, Silberring, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070521/
https://www.ncbi.nlm.nih.gov/pubmed/32069913
http://dx.doi.org/10.3390/molecules25040813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070521/
https://www.ncbi.nlm.nih.gov/pubmed/32069913
http://dx.doi.org/10.3390/molecules25040813

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