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Synthesis of the Novel Covalent Cysteine Proteases Inhibitor with Iodoacetic Functional Group
This work presents the synthesis of the novel covalent inhibitor of cysteine proteases where epoxide has been replaced by the iodoacetyl functional group. The molecule, similar in action to E-64 and DCG-04, the commonly applied inhibitors, is additionally biotinylated and contains tyrosyl iodination...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070521/ https://www.ncbi.nlm.nih.gov/pubmed/32069913 http://dx.doi.org/10.3390/molecules25040813 |