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Biological Activity Profiles of Multitarget Ligands from X-ray Structures

In pharmaceutical research, compounds with multitarget activity receive increasing attention. Such promiscuous chemical entities are prime candidates for polypharmacology, but also prone to causing undesired side effects. In addition, understanding the molecular basis and magnitude of multitarget ac...

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Detalles Bibliográficos
Autores principales: Feldmann, Christian, Bajorath, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070578/
https://www.ncbi.nlm.nih.gov/pubmed/32059498
http://dx.doi.org/10.3390/molecules25040794