Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

A series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic moiety (benzyl-piperidine/-piperazine) was designed, synthesized, and evaluated as potential anti-Alzheimer’s disease (AD) drugs in terms of biologic...

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Detalles Bibliográficos
Autores principales: Chaves, Sílvia, Resta, Simonetta, Rinaldo, Federica, Costa, Marina, Josselin, Romane, Gwizdala, Karolina, Piemontese, Luca, Capriati, Vito, Pereira-Santos, A. Raquel, Cardoso, Sandra M., Santos, M. Amélia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070709/
https://www.ncbi.nlm.nih.gov/pubmed/32098407
http://dx.doi.org/10.3390/molecules25040985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070709/
https://www.ncbi.nlm.nih.gov/pubmed/32098407
http://dx.doi.org/10.3390/molecules25040985

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