Cargando…

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

A series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic moiety (benzyl-piperidine/-piperazine) was designed, synthesized, and evaluated as potential anti-Alzheimer’s disease (AD) drugs in terms of biologic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chaves, Sílvia, Resta, Simonetta, Rinaldo, Federica, Costa, Marina, Josselin, Romane, Gwizdala, Karolina, Piemontese, Luca, Capriati, Vito, Pereira-Santos, A. Raquel, Cardoso, Sandra M., Santos, M. Amélia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070709/ https://www.ncbi.nlm.nih.gov/pubmed/32098407 http://dx.doi.org/10.3390/molecules25040985

Ejemplares similares

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease
por: Queda, Fausto, et al.
Publicado: (2021)

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
por: Piemontese, Luca, et al.
Publicado: (2018)

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds
por: Piemontese, Luca, et al.
Publicado: (2020)

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases
por: Vicente-Zurdo, David, et al.
Publicado: (2023)

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease
por: Rajeshwari, Rajeshwari, et al.
Publicado: (2019)

N-Hydroxybenzimidazole as a structurally modifiable platform for N-oxyl radicals for direct C–H functionalization reactions
por: Yoshii, Tomomi, et al.
Publicado: (2020)

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
por: Green, Keith D., et al.
Publicado: (2018)

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease
por: Carocci, Alessia, et al.
Publicado: (2022)

Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders
por: Quezada, Elías, et al.
Publicado: (2021)

A Definition of “Multitargeticity”: Identifying Potential Multitarget and Selective Ligands Through a Vector Analysis
por: Sánchez-Tejeda, Juan Francisco, et al.
Publicado: (2020)

Design, Synthesis, In Silico Studies and In Vitro Evaluation of New Indole- and/or Donepezil-like Hybrids as Multitarget-Directed Agents for Alzheimer’s Disease
por: Angelova, Violina T., et al.
Publicado: (2023)

Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer’s disease
por: Junaid, Md., et al.
Publicado: (2019)

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
por: Unzeta, Mercedes, et al.
Publicado: (2016)

Synthetic Approaches for Piperidone-Based Templates as Scaffolds to Access Chirally Enriched Donepezil Analogues
por: Poeschl, Anna, et al.
Publicado: (2020)

Deep Eutectic Solvents as Novel and Effective Extraction Media for Quantitative Determination of Ochratoxin A in Wheat and Derived Products
por: Piemontese, Luca, et al.
Publicado: (2017)

Biological Activity Profiles of Multitarget Ligands from X-ray Structures
por: Feldmann, Christian, et al.
Publicado: (2020)

Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease
por: Hafez, Donia E., et al.
Publicado: (2023)

Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues
por: Caliandro, Rosanna, et al.
Publicado: (2018)

Pharmacogenetics of Donepezil and Memantine in Healthy Subjects
por: Ovejero-Benito, María C., et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases
por: Bolognino, Isabella, et al.
Publicado: (2021)

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
por: Dakhlaoui, Imen, et al.
Publicado: (2023)

Comparison of Steady-State Pharmacokinetics of Donepezil Transdermal Delivery System with Oral Donepezil
por: Tariot, Pierre N., et al.
Publicado: (2022)

Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease
por: Prati, Federica, et al.
Publicado: (2016)

Effects of Linkers and Substitutions on Multitarget Directed Ligands for Alzheimer’s Diseases: Emerging Paradigms and Strategies
por: Pravin, Narayanaperumal, et al.
Publicado: (2022)

Multitargeting Histamine H(3) Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives
por: Łażewska, Dorota, et al.
Publicado: (2023)

N-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity
por: Krátký, Martin, et al.
Publicado: (2020)

Reshaping Ullmann Amine Synthesis in Deep Eutectic Solvents: A Mild Approach for Cu-Catalyzed C–N Coupling Reactions With No Additional Ligands
por: Quivelli, Andrea Francesca, et al.
Publicado: (2019)

Pd-Catalyzed Direct Modification of an Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of α-Aryl Donepezil Analogues
por: Wan, Lin-Xi, et al.
Publicado: (2021)

Ligand Selectivity between the ADP-Ribosylating Toxins: An Inverse-Docking Study for Multitarget Drug Discovery
por: Saenz-Méndez, Patricia, et al.
Publicado: (2017)

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease
por: Vicente-Zurdo, David, et al.
Publicado: (2022)

Donepezil Beyond Alzheimer's Disease? A Narrative Review of Therapeutic Potentials of Donepezil in Different Diseases
por: Pooladgar, Parham, et al.
Publicado: (2022)

“Statistics 103” for Multitarget Tracking
por: Mahler, Ronald
Publicado: (2019)

Multitarget Therapeutics for Neurodegenerative Diseases
por: Gabr, Moustafa T., et al.
Publicado: (2020)

Hippocampal Avoidance in Multitarget Radiosurgery
por: Gude, Zachary, et al.
Publicado: (2021)

Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies
por: Gil-Edo, Raquel, et al.
Publicado: (2023)

Transdermal donepezil on the treatment of Alzheimer’s disease
por: Sozio, Piera, et al.
Publicado: (2012)

Durable recovery from amblyopia with donepezil
por: Wu, Carolyn, et al.
Publicado: (2023)

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease
por: Piemontese, Luca, et al.
Publicado: (2018)

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease
por: Fancellu, Gaia, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels
por: Pachòn Angona, Irene, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lnf6d83it3ms923qd7s69oma83