Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na(v)1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special interest in the Na(v)1.7 subtype, which is expressed...

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Detalles Bibliográficos
Autores principales: Siebenga, Pieter, van Amerongen, Guido, Hay, Justin L., McDonnell, Aoibhinn, Gorman, Donal, Butt, Richard, Groeneveld, Geert Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070789/
https://www.ncbi.nlm.nih.gov/pubmed/31642607
http://dx.doi.org/10.1111/cts.12712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070789/
https://www.ncbi.nlm.nih.gov/pubmed/31642607
http://dx.doi.org/10.1111/cts.12712

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