Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

Reliably predicting in vivo efficacy from in vitro data would facilitate drug development by reducing animal usage and guiding drug dosing in human clinical trials. However, such prediction remains challenging. Here, we built a quantitative pharmacokinetic/pharmacodynamic (PK/PD) mathematical model...

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Detalles Bibliográficos
Autores principales: Bouhaddou, Mehdi, Yu, Li J., Lunardi, Serena, Stamatelos, Spyros K., Mack, Fiona, Gallo, James M., Birtwistle, Marc R., Walz, Antje‐Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070804/
https://www.ncbi.nlm.nih.gov/pubmed/31729169
http://dx.doi.org/10.1111/cts.12727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070804/
https://www.ncbi.nlm.nih.gov/pubmed/31729169
http://dx.doi.org/10.1111/cts.12727

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