Cargando…

Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer

Reliably predicting in vivo efficacy from in vitro data would facilitate drug development by reducing animal usage and guiding drug dosing in human clinical trials. However, such prediction remains challenging. Here, we built a quantitative pharmacokinetic/pharmacodynamic (PK/PD) mathematical model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bouhaddou, Mehdi, Yu, Li J., Lunardi, Serena, Stamatelos, Spyros K., Mack, Fiona, Gallo, James M., Birtwistle, Marc R., Walz, Antje‐Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070804/ https://www.ncbi.nlm.nih.gov/pubmed/31729169 http://dx.doi.org/10.1111/cts.12727

Ejemplares similares

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array
por: Koch, Rick J., et al.
Publicado: (2018)

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma
por: Jones, DeAnalisa C., et al.
Publicado: (2018)

Network inference from perturbation time course data
por: Sarmah, Deepraj, et al.
Publicado: (2022)

Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide
por: Saini, Anshul, et al.
Publicado: (2023)

Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior
por: Stamatelos, Spyros K, et al.
Publicado: (2011)

Tumor Ensemble-Based Modeling and Visualization of Emergent Angiogenic Heterogeneity in Breast Cancer
por: Stamatelos, Spyros K., et al.
Publicado: (2019)

Quantitative systems pharmacology modeling sheds light into the dose response relationship of a trispecific T cell engager in multiple myeloma
por: Abrams, R. E., et al.
Publicado: (2022)

Manual técnico del banco de sangre
por: Albarrán de Stamatelos, Cecilia
Publicado: (1985)

A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens
por: Bouhaddou, Mehdi, et al.
Publicado: (2018)

Epigenetic effects of pharmacologic ascorbate
por: Steers, Garett J., et al.
Publicado: (2021)

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling
por: Erdem, Cemal, et al.
Publicado: (2022)

A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis
por: Van De Vyver, Arthur, et al.
Publicado: (2021)

Editorial: Role of Epigenetics in Autoimmune Diseases
por: Dolcino, Marzia, et al.
Publicado: (2020)

DIPG-12. TARGETING EPIGENETIC MODIFIERS TO INDUCE IMMUNE SIGNALING IN DIPG
por: Tetens, Ashley, et al.
Publicado: (2020)

Linear Approaches to Intramolecular Förster Resonance Energy Transfer Probe Measurements for Quantitative Modeling
por: Birtwistle, Marc R., et al.
Publicado: (2011)

The emerging landscape of in vitro and in vivo epigenetic allelic effects
por: Gregg, Christopher
Publicado: (2017)

Underlying features of epigenetic aging clocks in vivo and in vitro
por: Liu, Zuyun, et al.
Publicado: (2020)

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions
por: Chan, Anthony K. N., et al.
Publicado: (2019)

Ex-Vivo Pharmacological Defatting of the Liver: A Review
por: Goumard, Claire, et al.
Publicado: (2021)

Qualitative and quantitative analyses of chemical constituents in vitro and in vivo and systematic evaluation of the pharmacological effects of Tibetan medicine Zhixue Zhentong capsules
por: Song, Yinglian, et al.
Publicado: (2023)

Validation of epigenetic mechanisms regulating gene expression in canine B-cell lymphoma: An in vitro and in vivo approach
por: Da Ros, Silvia, et al.
Publicado: (2018)

Immunological Effects of Epigenetic Modifiers
por: Bezu, Lucillia, et al.
Publicado: (2019)

Industrialization of Quantitative Systems Pharmacology
por: Topp, Brian, et al.
Publicado: (2019)

In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination
por: Merrill, Jean E
Publicado: (2008)

Current proteomics methods applicable to dissecting the DNA damage response
por: Muralidharan, Monita, et al.
Publicado: (2023)

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB(1)) Receptor Antagonist
por: Hadcock, John R, et al.
Publicado: (2010)

Ex vivo multiscale quantitation of skin biomechanics in wild-type and genetically-modified mice using multiphoton microscopy
por: Bancelin, Stéphane, et al.
Publicado: (2015)

A large-scale dataset of in vivo pharmacology assay results
por: Hunter, Fiona M. I., et al.
Publicado: (2018)

Mechanistic Vs. Empirical Network Models of Drug Action
por: Birtwistle, M R, et al.
Publicado: (2013)

A General Network Pharmacodynamic Model–Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway
por: Zhang, X-Y, et al.
Publicado: (2014)

Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription
por: Morgan, Marc A. J., et al.
Publicado: (2023)

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative
por: Ruzza, Chiara, et al.
Publicado: (2015)

In vivo and in vitro evaluation of pharmacological activities of Adenia trilobata (Roxb.)
por: Barua, Niloy, et al.
Publicado: (2020)

QUANTITATIVE METHODS IN HUMAN PHARMACOLOGY AND THERAPEUTICS
Publicado: (1959)

Logic Modeling in Quantitative Systems Pharmacology
por: Traynard, Pauline, et al.
Publicado: (2017)

Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
por: Rushton, Michael D., et al.
Publicado: (2015)

Systematic Review of Epigenetic Effects of Pharmacological Agents for Bipolar Disorders
por: Lockwood, Laura E., et al.
Publicado: (2017)

Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney disease
por: Haarhaus, Mathias, et al.
Publicado: (2020)

Validation of housekeeping genes for quantitative real-time PCR in in-vivo and in-vitro models of cerebral ischaemia
por: Gubern, Carme, et al.
Publicado: (2009)

Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model
por: Nikfar, Mehdi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eb700ptmsklotihl5pigfrm5c8