Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing. We examined the impact of itraconazole on ibrutinib pharmacokinetics. In a randomized crosso...

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Detalles Bibliográficos
Autores principales: Tapaninen, Tuija, Olkkola, Aleksi M., Tornio, Aleksi, Neuvonen, Mikko, Elonen, Erkki, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070818/
https://www.ncbi.nlm.nih.gov/pubmed/31664782
http://dx.doi.org/10.1111/cts.12716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070818/
https://www.ncbi.nlm.nih.gov/pubmed/31664782
http://dx.doi.org/10.1111/cts.12716

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