Enhanced Hybridization Selectivity Using Structured GammaPNA Probes

High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off-target binding to mismatch-containing sequences. We introduced a hairpin secondary structure into a γPNA oligomer to enhance...

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Detalles Bibliográficos
Autores principales: Canady, Taylor D., Berlyoung, April S., Martinez, Joe A., Emanuelson, Cole, Telmer, Cheryl A., Bruchez, Marcel P., Armitage, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070858/
https://www.ncbi.nlm.nih.gov/pubmed/32098111
http://dx.doi.org/10.3390/molecules25040970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070858/
https://www.ncbi.nlm.nih.gov/pubmed/32098111
http://dx.doi.org/10.3390/molecules25040970

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