Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy

Pharmacokinetic (PK) variability in cancer clinical trials may be due to heterogeneous populations and identifying sources of variability is important. Use of healthy subjects in clinical pharmacology studies together with detailed knowledge of the characteristics of patients with cancer can allow f...

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Detalles Bibliográficos
Autores principales: Reyner, Eric, Lum, Bert, Jing, Jing, Kagedal, Matts, Ware, Joseph A., Dickmann, Leslie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070882/
https://www.ncbi.nlm.nih.gov/pubmed/31729137
http://dx.doi.org/10.1111/cts.12726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070882/
https://www.ncbi.nlm.nih.gov/pubmed/31729137
http://dx.doi.org/10.1111/cts.12726

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