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Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy
Pharmacokinetic (PK) variability in cancer clinical trials may be due to heterogeneous populations and identifying sources of variability is important. Use of healthy subjects in clinical pharmacology studies together with detailed knowledge of the characteristics of patients with cancer can allow f...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070882/ https://www.ncbi.nlm.nih.gov/pubmed/31729137 http://dx.doi.org/10.1111/cts.12726 |