Ultrafast Backbone Protonation in Channelrhodopsin-1 Captured by Polarization Resolved Fs Vis-pump—IR-Probe Spectroscopy and Computational Methods

Channelrhodopsins (ChR) are light-gated ion-channels heavily used in optogenetics. Upon light excitation an ultrafast all-trans to 13-cis isomerization of the retinal chromophore takes place. It is still uncertain by what means this reaction leads to further protein changes and channel conductivity....

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Detalles Bibliográficos
Autores principales: Stensitzki, Till, Adam, Suliman, Schlesinger, Ramona, Schapiro, Igor, Heyne, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070883/
https://www.ncbi.nlm.nih.gov/pubmed/32075128
http://dx.doi.org/10.3390/molecules25040848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070883/
https://www.ncbi.nlm.nih.gov/pubmed/32075128
http://dx.doi.org/10.3390/molecules25040848

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