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Ultrafast Backbone Protonation in Channelrhodopsin-1 Captured by Polarization Resolved Fs Vis-pump—IR-Probe Spectroscopy and Computational Methods
Channelrhodopsins (ChR) are light-gated ion-channels heavily used in optogenetics. Upon light excitation an ultrafast all-trans to 13-cis isomerization of the retinal chromophore takes place. It is still uncertain by what means this reaction leads to further protein changes and channel conductivity....
Autores principales: | Stensitzki, Till, Adam, Suliman, Schlesinger, Ramona, Schapiro, Igor, Heyne, Karsten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070883/ https://www.ncbi.nlm.nih.gov/pubmed/32075128 http://dx.doi.org/10.3390/molecules25040848 |
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