Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide

As opposed to small molecules, macrocyclic peptides possess a large surface area and are recognised as promising candidates to selectively treat diseases by disrupting specific protein–protein interactions (PPIs). Due to the difficulty in predicting cyclopeptide conformations in solution, the de nov...

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Detalles Bibliográficos
Autores principales: Idress, Mohannad, Milne, Bruce F., Thompson, Gary S., Trembleau, Laurent, Jaspars, Marcel, Houssen, Wael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071015/
https://www.ncbi.nlm.nih.gov/pubmed/32093030
http://dx.doi.org/10.3390/molecules25040922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071015/
https://www.ncbi.nlm.nih.gov/pubmed/32093030
http://dx.doi.org/10.3390/molecules25040922

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