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Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide
As opposed to small molecules, macrocyclic peptides possess a large surface area and are recognised as promising candidates to selectively treat diseases by disrupting specific protein–protein interactions (PPIs). Due to the difficulty in predicting cyclopeptide conformations in solution, the de nov...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071015/ https://www.ncbi.nlm.nih.gov/pubmed/32093030 http://dx.doi.org/10.3390/molecules25040922 |