In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study

A series of benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones were prepared from 2-acylnaphthohydroquinones and 2-aminobenzothiazoles and were evaluated for their in vitro antiproliferative activity. After screening using the MTT reduction assay, their IC(50) values were calculated on a panel of...

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Detalles Bibliográficos
Autores principales: Valderrama, Jaime A., Ríos, David, Muccioli, Giulio G., Buc Calderon, Pedro, Benites, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071032/
https://www.ncbi.nlm.nih.gov/pubmed/32093392
http://dx.doi.org/10.3390/molecules25040953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071032/
https://www.ncbi.nlm.nih.gov/pubmed/32093392
http://dx.doi.org/10.3390/molecules25040953

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