Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfuryl moiety of the well-known antiangiogenic 2-fury...

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Detalles Bibliográficos
Autores principales: Abdel-Mohsen, Heba T., Abdullaziz, Mona A., El Kerdawy, Ahmed M., Ragab, Fatma A. F., Flanagan, Keith J., Mahmoud, Abeer E. E., Ali, Mamdouh M., El Diwani, Hoda I., Senge, Mathias O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071059/
https://www.ncbi.nlm.nih.gov/pubmed/32053964
http://dx.doi.org/10.3390/molecules25040770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071059/
https://www.ncbi.nlm.nih.gov/pubmed/32053964
http://dx.doi.org/10.3390/molecules25040770

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