How Different Substitution Positions of F, Cl Atoms in Benzene Ring of 5-Methylpyrimidine Pyridine Derivatives Affect the Inhibition Ability of EGFR(L858R/T790M/C797S) Inhibitors: A Molecular Dynamics Simulation Study

Lung cancer is the most frequent cause of cancer-related deaths worldwide, and mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are a common cause of non-small-cell lung cancers, which is a major subtype of lung cancers. Recently, a series of 5-methylpyrimidine-pyridinon...

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Detalles Bibliográficos
Autores principales: E, Jingwen, Liu, Ye, Guan, Shanshan, Luo, Zhijian, Han, Fei, Han, Weiwei, Wang, Song, Zhang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071101/
https://www.ncbi.nlm.nih.gov/pubmed/32085409
http://dx.doi.org/10.3390/molecules25040895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071101/
https://www.ncbi.nlm.nih.gov/pubmed/32085409
http://dx.doi.org/10.3390/molecules25040895

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