Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2E1 Enzyme Activity: Inhibitory Effect of Cytochrome P450 Enzyme CYP2E1 by Salicylic Acid in Rat Liver Microsomes

Inhibition of cytochrome P450 (CYP) alters the pharmacokinetic parameters of the drug and causes drug–drug interactions. Salicylic acid been used for the treatment of colorectal cancer (CRC) and chemoprevention in recent decades. Thus, the aim of this study was to examine the in vitro inhibitory eff...

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Detalles Bibliográficos
Autores principales: Salhab, Hassan, Naughton, Declan P., Barker, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071109/
https://www.ncbi.nlm.nih.gov/pubmed/32093091
http://dx.doi.org/10.3390/molecules25040932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071109/
https://www.ncbi.nlm.nih.gov/pubmed/32093091
http://dx.doi.org/10.3390/molecules25040932

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