Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl(2) catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrim...

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Autores principales: Yazdani, Hossein, Kaul, Esha, Bazgir, Ayoob, Maysinger, Dusica, Kakkar, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071137/
https://www.ncbi.nlm.nih.gov/pubmed/32075239
http://dx.doi.org/10.3390/molecules25040857
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author Yazdani, Hossein
Kaul, Esha
Bazgir, Ayoob
Maysinger, Dusica
Kakkar, Ashok
author_facet Yazdani, Hossein
Kaul, Esha
Bazgir, Ayoob
Maysinger, Dusica
Kakkar, Ashok
author_sort Yazdani, Hossein
collection PubMed
description An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl(2) catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.
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spelling pubmed-70711372020-03-19 Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology Yazdani, Hossein Kaul, Esha Bazgir, Ayoob Maysinger, Dusica Kakkar, Ashok Molecules Article An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl(2) catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival. MDPI 2020-02-15 /pmc/articles/PMC7071137/ /pubmed/32075239 http://dx.doi.org/10.3390/molecules25040857 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yazdani, Hossein
Kaul, Esha
Bazgir, Ayoob
Maysinger, Dusica
Kakkar, Ashok
Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
title Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
title_full Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
title_fullStr Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
title_full_unstemmed Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
title_short Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology
title_sort telodendrimer-based macromolecular drug design using 1,3-dipolar cycloaddition for applications in biology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071137/
https://www.ncbi.nlm.nih.gov/pubmed/32075239
http://dx.doi.org/10.3390/molecules25040857
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