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A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects
Background: Healthy plant-based diets rich in fermentable residues may induce gas-related symptoms. Our aim was to determine the potential of a fermented milk product with probiotics in improving digestive comfort with such diets. Methods: In an open design, a 3-day high-residue diet was administere...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071254/ https://www.ncbi.nlm.nih.gov/pubmed/31991794 http://dx.doi.org/10.3390/nu12020320 |
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author | Le Nevé, Boris Martinez-De la Torre, Adrian Tap, Julien Derrien, Muriel Cotillard, Aurélie Barba, Elizabeth Mego, Marianela Nieto Ruiz, Adoración Hernandez-Palet, Laura Dornic, Quentin Faurie, Jean-Michel Butler, John Merino, Xavi Lobo, Beatriz Pinsach Batet, Ferran Accarino, Anna Pozuelo, Marta Manichanh, Chaysavanh Azpiroz, Fernando |
author_facet | Le Nevé, Boris Martinez-De la Torre, Adrian Tap, Julien Derrien, Muriel Cotillard, Aurélie Barba, Elizabeth Mego, Marianela Nieto Ruiz, Adoración Hernandez-Palet, Laura Dornic, Quentin Faurie, Jean-Michel Butler, John Merino, Xavi Lobo, Beatriz Pinsach Batet, Ferran Accarino, Anna Pozuelo, Marta Manichanh, Chaysavanh Azpiroz, Fernando |
author_sort | Le Nevé, Boris |
collection | PubMed |
description | Background: Healthy plant-based diets rich in fermentable residues may induce gas-related symptoms. Our aim was to determine the potential of a fermented milk product with probiotics in improving digestive comfort with such diets. Methods: In an open design, a 3-day high-residue diet was administered to healthy subjects (n = 74 included, n = 63 completed) before and following 28 days consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria. Main outcomes: digestive sensations, number of daytime anal gas evacuations, and gas volume evacuated during 4 h after a probe meal. Results: As compared to the habitual diet, the high-residue diet induced gas-related symptoms (flatulence score 4.9 vs. 1.2; p ≤ 0.0001), increased the daily number of anal gas evacuations (20.7 vs. 8.7; p < 0.0001), and impaired digestive well-being (1.0 vs. 3.4; p < 0.05). FMP consumption reduced flatulence sensation (by −1.7 [−1.9; −1.6]; p < 0.0001), reduced the number of daily evacuations (by −5.8 [−6.5; −5.1]; p < 0.0001), and improved digestive well-being (by +0.6 [+0.4; +0.7]; p < 0.05). FMP consumption did not affect the gas volume evacuated after a probe meal. Conclusion: In healthy subjects, consumption of a FMP containing B. lactis CNCM I-2494 and lactic acid bacteria improves the tolerance of a flatulogenic diet by subjective and objective criteria (sensations and number of anal gas evacuations, respectively). |
format | Online Article Text |
id | pubmed-7071254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70712542020-03-19 A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects Le Nevé, Boris Martinez-De la Torre, Adrian Tap, Julien Derrien, Muriel Cotillard, Aurélie Barba, Elizabeth Mego, Marianela Nieto Ruiz, Adoración Hernandez-Palet, Laura Dornic, Quentin Faurie, Jean-Michel Butler, John Merino, Xavi Lobo, Beatriz Pinsach Batet, Ferran Accarino, Anna Pozuelo, Marta Manichanh, Chaysavanh Azpiroz, Fernando Nutrients Article Background: Healthy plant-based diets rich in fermentable residues may induce gas-related symptoms. Our aim was to determine the potential of a fermented milk product with probiotics in improving digestive comfort with such diets. Methods: In an open design, a 3-day high-residue diet was administered to healthy subjects (n = 74 included, n = 63 completed) before and following 28 days consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria. Main outcomes: digestive sensations, number of daytime anal gas evacuations, and gas volume evacuated during 4 h after a probe meal. Results: As compared to the habitual diet, the high-residue diet induced gas-related symptoms (flatulence score 4.9 vs. 1.2; p ≤ 0.0001), increased the daily number of anal gas evacuations (20.7 vs. 8.7; p < 0.0001), and impaired digestive well-being (1.0 vs. 3.4; p < 0.05). FMP consumption reduced flatulence sensation (by −1.7 [−1.9; −1.6]; p < 0.0001), reduced the number of daily evacuations (by −5.8 [−6.5; −5.1]; p < 0.0001), and improved digestive well-being (by +0.6 [+0.4; +0.7]; p < 0.05). FMP consumption did not affect the gas volume evacuated after a probe meal. Conclusion: In healthy subjects, consumption of a FMP containing B. lactis CNCM I-2494 and lactic acid bacteria improves the tolerance of a flatulogenic diet by subjective and objective criteria (sensations and number of anal gas evacuations, respectively). MDPI 2020-01-25 /pmc/articles/PMC7071254/ /pubmed/31991794 http://dx.doi.org/10.3390/nu12020320 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Le Nevé, Boris Martinez-De la Torre, Adrian Tap, Julien Derrien, Muriel Cotillard, Aurélie Barba, Elizabeth Mego, Marianela Nieto Ruiz, Adoración Hernandez-Palet, Laura Dornic, Quentin Faurie, Jean-Michel Butler, John Merino, Xavi Lobo, Beatriz Pinsach Batet, Ferran Accarino, Anna Pozuelo, Marta Manichanh, Chaysavanh Azpiroz, Fernando A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects |
title | A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects |
title_full | A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects |
title_fullStr | A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects |
title_full_unstemmed | A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects |
title_short | A Fermented Milk Product with B. lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects |
title_sort | fermented milk product with b. lactis cncm i-2494 and lactic acid bacteria improves gastrointestinal comfort in response to a challenge diet rich in fermentable residues in healthy subjects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071254/ https://www.ncbi.nlm.nih.gov/pubmed/31991794 http://dx.doi.org/10.3390/nu12020320 |
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