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Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress
In this brief review, we present evidence of the primary role of learning-associated plasticity in the development of either adaptive or maladaptive coping strategies. Successful interactions with novel stressors foster plasticity within the neural circuits supporting acquisition, consolidation, ret...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071431/ https://www.ncbi.nlm.nih.gov/pubmed/32102272 http://dx.doi.org/10.3390/brainsci10020127 |
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author | Cabib, Simona Campus, Paolo Conversi, David Orsini, Cristina Puglisi-Allegra, Stefano |
author_facet | Cabib, Simona Campus, Paolo Conversi, David Orsini, Cristina Puglisi-Allegra, Stefano |
author_sort | Cabib, Simona |
collection | PubMed |
description | In this brief review, we present evidence of the primary role of learning-associated plasticity in the development of either adaptive or maladaptive coping strategies. Successful interactions with novel stressors foster plasticity within the neural circuits supporting acquisition, consolidation, retrieval, and extinction of instrumental learning leading to development of a rich repertoire of flexible and context-specific adaptive coping responses, whereas prolonged or repeated exposure to inescapable/uncontrollable stressors fosters dysfunctional plasticity within the learning circuits leading to perseverant and inflexible maladaptive coping strategies. Finally, the results collected using an animal model of genotype-specific coping styles indicate the engagement of different molecular networks and the opposite direction of stress effects (reduced vs. enhanced gene expression) in stressed animals, as well as different behavioral alterations, in line with differences in the symptoms profile associated with post-traumatic stress disorder. |
format | Online Article Text |
id | pubmed-7071431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70714312020-03-19 Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress Cabib, Simona Campus, Paolo Conversi, David Orsini, Cristina Puglisi-Allegra, Stefano Brain Sci Opinion In this brief review, we present evidence of the primary role of learning-associated plasticity in the development of either adaptive or maladaptive coping strategies. Successful interactions with novel stressors foster plasticity within the neural circuits supporting acquisition, consolidation, retrieval, and extinction of instrumental learning leading to development of a rich repertoire of flexible and context-specific adaptive coping responses, whereas prolonged or repeated exposure to inescapable/uncontrollable stressors fosters dysfunctional plasticity within the learning circuits leading to perseverant and inflexible maladaptive coping strategies. Finally, the results collected using an animal model of genotype-specific coping styles indicate the engagement of different molecular networks and the opposite direction of stress effects (reduced vs. enhanced gene expression) in stressed animals, as well as different behavioral alterations, in line with differences in the symptoms profile associated with post-traumatic stress disorder. MDPI 2020-02-24 /pmc/articles/PMC7071431/ /pubmed/32102272 http://dx.doi.org/10.3390/brainsci10020127 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Cabib, Simona Campus, Paolo Conversi, David Orsini, Cristina Puglisi-Allegra, Stefano Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress |
title | Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress |
title_full | Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress |
title_fullStr | Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress |
title_full_unstemmed | Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress |
title_short | Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress |
title_sort | functional and dysfunctional neuroplasticity in learning to cope with stress |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071431/ https://www.ncbi.nlm.nih.gov/pubmed/32102272 http://dx.doi.org/10.3390/brainsci10020127 |
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