Cargando…

Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells

Pancreatic β-cells secrete insulin to lower blood glucose, following a meal. Maintenance of β-cell function is essential to preventing type 2 diabetes. In pancreatic β-cells, mitochondrial matrix calcium is an activating signal for insulin secretion. Recently, the molecular identity of the mitochond...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bermont, Flavien, Hermant, Aurelie, Benninga, Romy, Chabert, Christian, Jacot, Guillaume, Santo-Domingo, Jaime, Kraus, Marine R-C, Feige, Jerome N., De Marchi, Umberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071504/ https://www.ncbi.nlm.nih.gov/pubmed/32093050 http://dx.doi.org/10.3390/nu12020538

Ejemplares similares

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state
por: Weiser, Anna, et al.
Publicado: (2023)

Inhibition of Staphylococcus aureus PriA Helicase by Flavonol Kaempferol
por: Huang, Yen-Hua, et al.
Publicado: (2015)

Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
por: Kubina, Robert, et al.
Publicado: (2021)

L‐OPA1 regulates mitoflash biogenesis independently from membrane fusion
por: Rosselin, Manon, et al.
Publicado: (2017)

Molecular Pathways Involved in the Anti-Cancer Activity of Flavonols: A Focus on Myricetin and Kaempferol
por: Felice, Maria Rosa, et al.
Publicado: (2022)

The Dietary Flavonol Kaempferol Inhibits Epstein–Barr Virus Reactivation in Nasopharyngeal Carcinoma Cells
por: Wu, Chung-Chun, et al.
Publicado: (2022)

Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis
por: Fernández-del-Río, Lucía, et al.
Publicado: (2020)

Kaempferol 3-O-rhamnoside-7-O-rhamnoside is an endogenous flavonol inhibitor of polar auxin transport in Arabidopsis shoots
por: Yin, Ruohe, et al.
Publicado: (2014)

Genetic Variation of Flavonols Quercetin, Myricetin, and Kaempferol in the Sri Lankan Tea (Camellia sinensis L.) and Their Health-Promoting Aspects
por: Jeganathan, Brasathe, et al.
Publicado: (2016)

Calcium Co-regulates Oxidative Metabolism and ATP Synthase-dependent Respiration in Pancreatic Beta Cells
por: De Marchi, Umberto, et al.
Publicado: (2014)

Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties
por: Rho, Ho Sik, et al.
Publicado: (2011)

Inhibition of CpLIP2 Lipase Hydrolytic Activity by Four Flavonols (Galangin, Kaempferol, Quercetin, Myricetin) Compared to Orlistat and Their Binding Mechanisms Studied by Quenching of Fluorescence
por: Nasri, Ruba, et al.
Publicado: (2019)

Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates
por: Mei, Qinggang, et al.
Publicado: (2015)

Mitochondrial Calcium Signaling in Pancreatic β-Cell
por: Weiser, Anna, et al.
Publicado: (2021)

Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltransferase BGLU6
por: Ishihara, Hirofumi, et al.
Publicado: (2016)

Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
por: Zhang, Li-Jie, et al.
Publicado: (2011)

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells
por: Santo-Domingo, Jaime, et al.
Publicado: (2019)

Characterization of the Brassica napus Flavonol Synthase Gene Family Reveals Bifunctional Flavonol Synthases
por: Schilbert, Hanna Marie, et al.
Publicado: (2021)

The Impact of Flavonols on Cardiovascular Risk
por: Popiolek-Kalisz, Joanna, et al.
Publicado: (2022)

Human myogenic reserve cells are quiescent stem cells that contribute to muscle regeneration after intramuscular transplantation in immunodeficient mice
por: Laumonier, Thomas, et al.
Publicado: (2017)

Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol
por: Wang, Jingqiu, et al.
Publicado: (2018)

Effects of Parsley (Petroselinum crispum) and its Flavonol Constituents, Kaempferol and Quercetin, on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Liver Xanthine Oxidoreductase Aactivity inOxonate-Induced Hyperuricemic Rats
por: Haidari, Fatemeh, et al.
Publicado: (2011)

Synthesis of a library of glycosylated flavonols
por: Li, Zhitao, et al.
Publicado: (2008)

Targeting Cardiovascular Diseases by Flavonols: An Update
por: Kozłowska, Aleksandra, et al.
Publicado: (2022)

Myricetin: a Multifunctional Flavonol in Biomedicine
por: Agraharam, Gopikrishna, et al.
Publicado: (2022)

Feedback inhibition of the general phenylpropanoid and flavonol biosynthetic pathways upon a compromised flavonol-3-O-glycosylation
por: Yin, Ruohe, et al.
Publicado: (2012)

Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae
por: Duan, Lijin, et al.
Publicado: (2017)

Cardioprotective Properties of Kaempferol: A Review
por: Kamisah, Yusof, et al.
Publicado: (2023)

In vitro anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca
por: Behbahani, M., et al.
Publicado: (2014)

Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes
por: De Marchi, Umberto, et al.
Publicado: (2020)

Kaempferol and Its Glycoside, Kaempferol 7-O-rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro
por: Kim, Ji Hye, et al.
Publicado: (2020)

Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction
por: Leo, Chen-Huei, et al.
Publicado: (2015)

Anti-androgenic effects of flavonols in prostate cancer
por: Boam, Tristan
Publicado: (2015)

Preventing and Treating Neurological Disorders with the Flavonol Fisetin
por: Maher, Pamela
Publicado: (2021)

The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation
por: Kim, Chang-Ju, et al.
Publicado: (2018)

Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma
por: Sharma, Nidhi, et al.
Publicado: (2021)

Therapeutic potential of kaempferol on Streptococcus pneumoniae infection
por: Xu, Lei, et al.
Publicado: (2023)

Molecular characterization and functional expression of flavonol 6-hydroxylase
por: Anzellotti, Dominique, et al.
Publicado: (2004)

Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza
por: Dayem, Ahmed Abdal, et al.
Publicado: (2015)

Synthesis of prenylated flavonols and their potents as estrogen receptor modulator
por: Tao, Zhenru, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_338j2nt1ffqed6hls43p9gusm0