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Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity

Background: The conversion of glutamic acid into γ-aminobutyric acid (GABA) is catalyzed by the glutamic acid decarboxylase (GAD). Antibodies against this enzyme have been described in neurological disorders, but the pathophysiological role of these antibodies is still poorly understood. We hypothes...

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Detalles Bibliográficos
Autores principales: Frerker, Bernd, Rohde, Marco, Müller, Steffen, Bien, Christian G., Köhling, Rüdiger, Kirschstein, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071523/
https://www.ncbi.nlm.nih.gov/pubmed/32098388
http://dx.doi.org/10.3390/brainsci10020123