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Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord

BACKGROUND: Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic pain. However, the mechanisms underlying spinal microglial activation during neuropathic pain remain incompletely determined. Here, we investigated the role of Pellino1 (Peli1) and its interplay with spinal mic...

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Detalles Bibliográficos
Autores principales: Wang, Lijuan, Yin, Cui, Liu, Tianya, Abdul, Mannan, Zhou, Yan, Cao, Jun-Li, Lu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071701/
https://www.ncbi.nlm.nih.gov/pubmed/32171293
http://dx.doi.org/10.1186/s12974-020-01754-z