STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Dysregulation of STAT3, a transcription factor pivotal to various cellular processes including Th17 cell differentiation, has been implicated in MS. Here, we report that STAT3 is activated in i...

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Detalles Bibliográficos
Autores principales: Lu, Hsueh Chung, Kim, Sunja, Steelman, Andrew J., Tracy, Kevin, Zhou, Beiyan, Michaud, Danielle, Hillhouse, Andrew E., Konganti, Kranti, Li, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071888/
https://www.ncbi.nlm.nih.gov/pubmed/32094172
http://dx.doi.org/10.1073/pnas.1913997117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071888/
https://www.ncbi.nlm.nih.gov/pubmed/32094172
http://dx.doi.org/10.1073/pnas.1913997117

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