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HIV-1 uncoats in the nucleus near sites of integration

HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic DNA into the host chromosomes, yet remarkably, the timing and cellular location of uncoating is unknown. Previous studies have proposed that intact viral cores are too large to fit through nuclear pores and unco...

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Detalles Bibliográficos
Autores principales: Burdick, Ryan C., Li, Chenglei, Munshi, MohamedHusen, Rawson, Jonathan M. O., Nagashima, Kunio, Hu, Wei-Shau, Pathak, Vinay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071919/
https://www.ncbi.nlm.nih.gov/pubmed/32094182
http://dx.doi.org/10.1073/pnas.1920631117