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Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53
The mutational landscape of p53 in cancer is unusual among tumor suppressors because most of the alterations are of the missense type and localize to a single domain: the ~220 amino acid DNA-binding domain. Nearly all of these mutations produce the common effect of reducing p53’s ability to interact...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072143/ https://www.ncbi.nlm.nih.gov/pubmed/32075132 http://dx.doi.org/10.3390/biom10020303 |