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Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1

SMAD ubiquitination regulatory factor 1 (Smurf1) is a Nedd4 family E3 ubiquitin ligase that regulates cell motility, polarity and TGFβ signaling. Smurf1 contains an N-terminal protein kinase C conserved 2 (C2) domain that targets cell membranes and is required for interactions with membrane-localize...

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Detalles Bibliográficos
Autores principales:	Scott, Jordan L., Frick, Cary T., Johnson, Kristen A., Liu, Haining, Yong, Sylvia S., Varney, Allyson G., Wiest, Olaf, Stahelin, Robert V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072158/ https://www.ncbi.nlm.nih.gov/pubmed/32033048 http://dx.doi.org/10.3390/biom10020229

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