Ipilimumab and Its Derived EGFR Aptamer-Based Conjugate Induce Efficient NK Cell Activation against Cancer Cells

The immune checkpoint CTLA-4 (cytotoxic T-lymphocyte-antigen 4), which inhibits the co-stimulatory CD28 signal on T cells, has been recently found expressed on other cell populations, such as tumor and natural killer (NK) cells. We tested for the first time the effects of ipilimumab, the human anti-...

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Detalles Bibliográficos
Autores principales: Passariello, Margherita, Camorani, Simona, Vetrei, Cinzia, Ricci, Stefania, Cerchia, Laura, De Lorenzo, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072174/
https://www.ncbi.nlm.nih.gov/pubmed/32024070
http://dx.doi.org/10.3390/cancers12020331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072174/
https://www.ncbi.nlm.nih.gov/pubmed/32024070
http://dx.doi.org/10.3390/cancers12020331

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