Cargando…

Are Glucosylceramide-Related Sphingolipids Involved in the Increased Risk for Cancer in Gaucher Disease Patients? Review and Hypotheses

The roles of ceramide and its catabolites, i.e., sphingosine and sphingosine 1-phosphate, in the development of malignancies and the response to anticancer regimens have been extensively described. Moreover, an abundant literature points to the effects of glucosylceramide synthase, the mammalian enz...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dubot, Patricia, Astudillo, Leonardo, Therville, Nicole, Sabourdy, Frédérique, Stirnemann, Jérôme, Levade, Thierry, Andrieu-Abadie, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072201/ https://www.ncbi.nlm.nih.gov/pubmed/32085512 http://dx.doi.org/10.3390/cancers12020475

Ejemplares similares

Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer
por: Dubot, Patricia, et al.
Publicado: (2022)

Pregnancy outcome in Refsum disease: Affected fetuses and children born to an affected mother
por: Dubot, Patricia, et al.
Publicado: (2019)

New Insights into the Role of Sphingolipid Metabolism in Melanoma
por: Carrié, Lorry, et al.
Publicado: (2020)

Sphingolipids modulate the epithelial–mesenchymal transition in cancer
por: Levade, T, et al.
Publicado: (2015)

Caspase-10-Dependent Cell Death in Fas/CD95 Signalling Is Not Abrogated by Caspase Inhibitor zVAD-fmk
por: Lafont, Elodie, et al.
Publicado: (2010)

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments
por: Stirnemann, Jérôme, et al.
Publicado: (2017)

First Report of a Patient with MPS Type VII, Due to Novel Mutations in GUSB, Who Underwent Enzyme Replacement and Then Hematopoietic Stem Cell Transplantation
por: Dubot, Patricia, et al.
Publicado: (2019)

Low level of the plasma sphingolipid, glucosylceramide, is associated with thrombotic diseases
por: Deguchi, Hiroshi, et al.
Publicado: (2017)

Ubiquitous Transgene Expression of the Glucosylceramide-Synthesizing Enzyme Accelerates Glucosylceramide Accumulation and Storage Cells in a Gaucher Disease Mouse Model
por: Barnes, Sonya, et al.
Publicado: (2014)

Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma
por: Bilal, Fatima, et al.
Publicado: (2019)

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase
por: Henriques, Alexandre, et al.
Publicado: (2015)

CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease
por: Marshall, John, et al.
Publicado: (2016)

A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease
por: Fujii, Takahiro, et al.
Publicado: (2021)

The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes
por: Milhas, Delphine, et al.
Publicado: (2012)

Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma
por: Mrad, Marguerite, et al.
Publicado: (2016)

Immunoglobulin Abnormalities in Gaucher Disease: an Analysis of 278 Patients Included in the French Gaucher Disease Registry
por: Nguyen, Yann, et al.
Publicado: (2020)

Sphingolipids: the nexus between Gaucher disease and insulin resistance
por: Fuller, Maria
Publicado: (2010)

The TNF Paradox in Cancer Progression and Immunotherapy
por: Montfort, Anne, et al.
Publicado: (2019)

Corrigendum: The TNF Paradox in Cancer Progression and Immunotherapy
por: Montfort, Anne, et al.
Publicado: (2019)

Effects of sphingolipids overload on red blood cell properties in Gaucher disease
por: Dupuis, Lucie, et al.
Publicado: (2020)

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors
por: Baudoin-Dehoux, Cécile, et al.
Publicado: (2019)

Type 3 Gaucher disease, diagnostic in adulthood
por: Detollenaere, Charles, et al.
Publicado: (2017)

Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation
por: Paul, Ashim, et al.
Publicado: (2021)

Production of Multiple Brain-Like Ganglioside Species Is Dispensable for Fas-Induced Apoptosis of Lymphoid Cells
por: Popa, Iuliana, et al.
Publicado: (2011)

Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives
por: Pellerin, Laurence, et al.
Publicado: (2020)

Synthesis and Biological Properties of Fungal Glucosylceramide
por: Del Poeta, Maurizio, et al.
Publicado: (2014)

Imiglucerase in the management of Gaucher disease type 1: an evidence-based review of its place in therapy
por: Serratrice, Christine, et al.
Publicado: (2016)

The French Gaucher’s disease registry: clinical characteristics, complications and treatment of 562 patients
por: Stirnemann, Jérôme, et al.
Publicado: (2012)

Bone events and evolution of biologic markers in Gaucher disease before and during treatment
por: Stirnemann, Jérôme, et al.
Publicado: (2010)

Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells
por: Popovic, Zoran V., et al.
Publicado: (2017)

Correction: Synthesis and Biological Properties of Fungal Glucosylceramide
por: Del Poeta, Maurizio, et al.
Publicado: (2015)

Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease
por: Cabrera-Salazar, Mario A., et al.
Publicado: (2012)

Altered Sphingolipids Metabolism Damaged Mitochondrial Functions: Lessons Learned From Gaucher and Fabry Diseases
por: Ivanova, Margarita
Publicado: (2020)

Characterization of Scedosporium apiospermum Glucosylceramides and Their Involvement in Fungal Development and Macrophage Functions
por: Rollin-Pinheiro, Rodrigo, et al.
Publicado: (2014)

Age-Dependent Changes in the Sphingolipid Composition of Mouse CD4(+) T Cell Membranes and Immune Synapses Implicate Glucosylceramides in Age-Related T Cell Dysfunction
por: Molano, Alberto, et al.
Publicado: (2012)

Anti-TNF, a magic bullet in cancer immunotherapy?
por: Montfort, Anne, et al.
Publicado: (2019)

Pulmonary involvement in Gaucher disease
por: de Farias, Lucas de Pádua Gomes, et al.
Publicado: (2017)

Gaucher disease – bone involvement
por: Chis, Bogdan Augustin, et al.
Publicado: (2021)

The Link between Gaucher Disease and Parkinson’s Disease Sheds Light on Old and Novel Disorders of Sphingolipid Metabolism
por: Indellicato, Rossella, et al.
Publicado: (2019)

Targeting the Complement–Sphingolipid System in COVID-19 and Gaucher Diseases: Evidence for a New Treatment Strategy
por: Trivedi, Vyoma Snehal, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vbii8phl2r6ldrnhmakmtfstie