Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth

Cutaneous melanoma is the most aggressive skin cancer with notorious drug resistance. Inhibition of immune checkpoint molecules is one of the most promising approaches for cancer therapy. Herein, we show that RNAi mediated silencing of STAT3 expression in the tumor tissue robustly inhibit tumor grow...

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Detalles Bibliográficos
Autores principales: Ehexige, Ehexige, Bao, Mingming, Bazarjav, Purevbat, Yu, Xiang, Xiao, Hai, Han, Shuqin, Baigude, Huricha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072202/
https://www.ncbi.nlm.nih.gov/pubmed/32059541
http://dx.doi.org/10.3390/biom10020285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072202/
https://www.ncbi.nlm.nih.gov/pubmed/32059541
http://dx.doi.org/10.3390/biom10020285

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