Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies

Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)—the transfer of ADP-ribose chains onto amino acid residues—with a resultant modulation of protein function. Many targets of PARP-1/2-dependent PARylati...

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Detalles Bibliográficos
Autores principales: Yélamos, José, Moreno-Lama, Lucia, Jimeno, Jaime, Ali, Syed O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072203/
https://www.ncbi.nlm.nih.gov/pubmed/32046278
http://dx.doi.org/10.3390/cancers12020392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072203/
https://www.ncbi.nlm.nih.gov/pubmed/32046278
http://dx.doi.org/10.3390/cancers12020392

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