Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t(6)A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm(5)s(2)U34) are critical ASL modifications that have been linked to several human di...

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Detalles Bibliográficos
Autores principales: Pollo-Oliveira, Leticia, Klassen, Roland, Davis, Nick, Ciftci, Akif, Bacusmo, Jo Marie, Martinelli, Maria, DeMott, Michael S., Begley, Thomas J., Dedon, Peter C., Schaffrath, Raffael, de Crécy-Lagard, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072221/
https://www.ncbi.nlm.nih.gov/pubmed/32085421
http://dx.doi.org/10.3390/biom10020322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072221/
https://www.ncbi.nlm.nih.gov/pubmed/32085421
http://dx.doi.org/10.3390/biom10020322

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