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Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast
Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t(6)A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm(5)s(2)U34) are critical ASL modifications that have been linked to several human di...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072221/ https://www.ncbi.nlm.nih.gov/pubmed/32085421 http://dx.doi.org/10.3390/biom10020322 |