Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark

The five members of the family of tumor suppressors ING contain a Plant Homeodomain (PHD) that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3) with an affinity in the low micromolar range. Here, we use NMR to show that in the presence of 15% Ficoll 70, an inert macromolecular...

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Detalles Bibliográficos
Autores principales: Palacios, Alicia, Blanco, Francisco J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072245/
https://www.ncbi.nlm.nih.gov/pubmed/32033221
http://dx.doi.org/10.3390/biom10020234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072245/
https://www.ncbi.nlm.nih.gov/pubmed/32033221
http://dx.doi.org/10.3390/biom10020234

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