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Macromolecular Crowding Increases the Affinity of the PHD of ING4 for the Histone H3K4me3 Mark
The five members of the family of tumor suppressors ING contain a Plant Homeodomain (PHD) that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3) with an affinity in the low micromolar range. Here, we use NMR to show that in the presence of 15% Ficoll 70, an inert macromolecular...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072245/ https://www.ncbi.nlm.nih.gov/pubmed/32033221 http://dx.doi.org/10.3390/biom10020234 |