Cargando…

Secreted Phospholipase A(2)-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation–Fibrosis Link

Secreted phospholipase A(2)-IIA (sPLA(2)-IIA) is a pro-inflammatory protein associated with cardiovascular disorders, whose functions and underlying mechanisms in cardiac remodelling are still under investigation. We herein study the role of sPLA(2)-IIA in cardiac fibroblast (CFs)-to-myofibroblast d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Ruben, Gutierrez, Beatriz, Cordova, Claudia, San Roman, Alberto, Alvarez, Yolanda, Hernandez, Marita, Cachofeiro, Victoria, Nieto, Maria L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072256/ https://www.ncbi.nlm.nih.gov/pubmed/32046347 http://dx.doi.org/10.3390/cells9020396

Ejemplares similares

Secreted phospholipase A(2)-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding
por: Martín, Rubén, et al.
Publicado: (2012)

A dangerous liaison: Leptin and sPLA2-IIA join forces to induce proliferation and migration of astrocytoma cells
por: Martín, Rubén, et al.
Publicado: (2017)

Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A(2)
por: Mangini, Maria, et al.
Publicado: (2022)

Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase A(2)
por: Kim, Ryung Rae, et al.
Publicado: (2020)

Purification and biochemical characterization of a secreted group IIA chicken intestinal phospholipase A(2)
por: Karray, Aida, et al.
Publicado: (2011)

The interaction of secreted phospholipase A(2)-IIA with the microbiota alters its lipidome and promotes inflammation
por: Doré, Etienne, et al.
Publicado: (2022)

Oleanolic acid ameliorates intestinal alterations associated with EAE
por: Gutierrez, Beatriz, et al.
Publicado: (2020)

A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A(2) on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A(2)α
por: Rodríguez, Juan P., et al.
Publicado: (2020)

Group IIA secreted phospholipase A(2) controls skin carcinogenesis and psoriasis by shaping the gut microbiota
por: Miki, Yoshimi, et al.
Publicado: (2022)

A Secreted Phospholipase A(2) Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State
por: Giannotti, Karina Cristina, et al.
Publicado: (2019)

Group IIA secreted phospholipase A(2) inhibition by elemolic acid as a function of anti-inflammatory activity
por: Giresha, Aladahalli S., et al.
Publicado: (2022)

Interplay between C1-inhibitor and group IIA secreted phospholipase A(2) impairs their respective function
por: Ferrara, Anne Lise, et al.
Publicado: (2022)

Design of Group IIA Secreted/Synovial Phospholipase A(2) Inhibitors: An Oxadiazolone Derivative Suppresses Chondrocyte Prostaglandin E(2) Secretion
por: Ombetta, Jean-Edouard, et al.
Publicado: (2010)

Enhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain
por: Kabadi, Ami M., et al.
Publicado: (2014)

EGFR transactivates RON to drive oncogenic crosstalk
por: Franco Nitta, Carolina, et al.
Publicado: (2021)

Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation
por: Du, Huan, et al.
Publicado: (2023)

Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant Staphylococcus aureus to Human Group IIA-Secreted Phospholipase A(2) and Daptomycin
por: Kuijk, Marieke M., et al.
Publicado: (2022)

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts
por: Razdan, Neetu, et al.
Publicado: (2018)

Rapamycin Induces Transactivation of the EGFR and Increases Cell Survival
por: Chaturvedi, Deepti, et al.
Publicado: (2009)

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
por: Yang, Xiao-Pei, et al.
Publicado: (2016)

Critical Role of TLR2 and MyD88 for Functional Response of Macrophages to a Group IIA-Secreted Phospholipase A(2) from Snake Venom
por: Leiguez, Elbio, et al.
Publicado: (2014)

Brk/PTK6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR
por: Li, X, et al.
Publicado: (2012)

Functional skeletal muscle constructs from transdifferentiated human fibroblasts
por: Xu, Bin, et al.
Publicado: (2020)

Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes
por: McElroy, Steven J., et al.
Publicado: (2012)

Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A(2)-IIA in microvascular endothelial cells of the injured brain
por: Wang, Guansong, et al.
Publicado: (2012)

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A(2) to exert its bactericidal effects
por: van Hensbergen, Vincent P., et al.
Publicado: (2018)

Secretory Phospholipase A(2)-IIA and Cardiovascular Disease: A Mendelian Randomization Study
por: Holmes, Michael V., et al.
Publicado: (2013)

Serum Phospholipase A2-IIA, hs-CRP, and Lipids in Women With Subclinical Hypothyroidism
por: Shojaei Nik, Mohammad Hossein, et al.
Publicado: (2014)

Promoting effect of hepatitis B virus on the expressoin of phospholipase A2 group IIA
por: Zhu, Chengliang, et al.
Publicado: (2017)

Human Group IIA Phospholipase A(2)—Three Decades on from Its Discovery
por: Scott, Kieran F., et al.
Publicado: (2021)

Old but New: Group IIA Phospholipase A(2) as a Modulator of Gut Microbiota
por: Taketomi, Yoshitaka, et al.
Publicado: (2022)

Osteogenic transdifferentiation of primary human fibroblasts to osteoblast-like cells with human platelet lysate
por: Cayami, Ferdy K., et al.
Publicado: (2022)

Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
por: Yao, Qin, et al.
Publicado: (2009)

Interaction of macrophages with apoptotic cells inhibits transdifferentiation and invasion of lung fibroblasts
por: Kim, Yong-Bae, et al.
Publicado: (2017)

Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality?
por: Du, Juan, et al.
Publicado: (2023)

Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation
por: Crouchet, Emilie, et al.
Publicado: (2022)

Oleanolic Acid Controls Allergic and Inflammatory Responses in Experimental Allergic Conjunctivitis
por: Córdova, Claudia, et al.
Publicado: (2014)

Sinapicacid Inhibits Group IIA Secretory Phospholipase A(2) and Its Inflammatory Response in Mice
por: Giresha, Aladahalli S., et al.
Publicado: (2022)

Rat Group IIA Secreted Phospholipase A(2) Binds to Cytochrome c Oxidase and Inhibits Its Activity: A Possible Episode in the Development of Alzheimer’s Disease
por: Ivanušec, Adrijan, et al.
Publicado: (2022)

Retraction: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
por: Yao, Qin, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_u89mmkcv8vnh4gamges0c6rnfk