Structural Determinants Responsible for the Preferential Insertion of Ribonucleotides by Bacterial NHEJ PolDom

The catalytic active site of the Polymerization Domain (PolDom) of bacterial Ligase D is designed to promote realignments of the primer and template strands and extend mispaired 3′ ends. These features, together with the preferred use of ribonucleotides (NTPs) over deoxynucleotides (dNTPs), allow Po...

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Detalles Bibliográficos
Autores principales: Sánchez-Salvador, Alejandro, de Vega, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072297/
https://www.ncbi.nlm.nih.gov/pubmed/32019147
http://dx.doi.org/10.3390/biom10020203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072297/
https://www.ncbi.nlm.nih.gov/pubmed/32019147
http://dx.doi.org/10.3390/biom10020203

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