Investigation of a Direct Interaction between miR4749 and the Tumor Suppressor p53 by Fluorescence, FRET and Molecular Modeling

The interactions between the DNA binding domain (DBD) of the tumor suppressor p53 and miR4749, characterized by a high sequence similarity with the DNA Response Element (RE) of p53, was investigated by fluorescence spectroscopy combined with computational modeling and docking. Fluorescence quenching...

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Detalles Bibliográficos
Autores principales: Bizzarri, Anna Rita, Cannistraro, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072324/
https://www.ncbi.nlm.nih.gov/pubmed/32098369
http://dx.doi.org/10.3390/biom10020346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072324/
https://www.ncbi.nlm.nih.gov/pubmed/32098369
http://dx.doi.org/10.3390/biom10020346

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