Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy

Lysosomal accumulation of sunitinib has been suggested as an underlying mechanism of resistance. Here, we investigated if photochemical internalization (PCI), a technology for cytosolic release of drugs entrapped in endosomes and lysosomes, would activate lysosomal sequestered sunitinib. By super-re...

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Detalles Bibliográficos
Autores principales: Wong, Judith Jing Wen, Berstad, Maria Brandal, Fremstedal, Ane Sofie Viset, Berg, Kristian, Patzke, Sebastian, Sørensen, Vigdis, Peng, Qian, Selbo, Pål Kristian, Weyergang, Anette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072415/
https://www.ncbi.nlm.nih.gov/pubmed/32053965
http://dx.doi.org/10.3390/cancers12020417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072415/
https://www.ncbi.nlm.nih.gov/pubmed/32053965
http://dx.doi.org/10.3390/cancers12020417

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