Cargando…

Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy

Lysosomal accumulation of sunitinib has been suggested as an underlying mechanism of resistance. Here, we investigated if photochemical internalization (PCI), a technology for cytosolic release of drugs entrapped in endosomes and lysosomes, would activate lysosomal sequestered sunitinib. By super-re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Judith Jing Wen, Berstad, Maria Brandal, Fremstedal, Ane Sofie Viset, Berg, Kristian, Patzke, Sebastian, Sørensen, Vigdis, Peng, Qian, Selbo, Pål Kristian, Weyergang, Anette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072415/ https://www.ncbi.nlm.nih.gov/pubmed/32053965 http://dx.doi.org/10.3390/cancers12020417

Ejemplares similares

Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
por: Bull-Hansen, Bente, et al.
Publicado: (2015)

Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
por: Jerjes, Waseem, et al.
Publicado: (2020)

Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
por: Olsen, Cathrine Elisabeth, et al.
Publicado: (2019)

RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
por: Engebraaten, Olav, et al.
Publicado: (2021)

Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines
por: Šošić, Lara, et al.
Publicado: (2020)

Multi-Modality Therapeutics with Potent Anti-Tumor Effects: Photochemical Internalization Enhances Delivery of the Fusion Toxin scFvMEL/rGel
por: Selbo, Pål K., et al.
Publicado: (2009)

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition
por: Nowak-Sliwinska, P, et al.
Publicado: (2015)

Production of Recombinant Gelonin Using an Automated Liquid Chromatography System
por: Berstad, Maria E. B., et al.
Publicado: (2020)

Photochemical internalization
por: Jerjes, Waseem, et al.
Publicado: (2010)

Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
por: Dietze, A, et al.
Publicado: (2005)

5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
por: Lund, Kaja, et al.
Publicado: (2017)

Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy
por: Prasmickaite, L, et al.
Publicado: (2002)

Aberrant Phase Separation of FUS Leads to Lysosome Sequestering and Acidification
por: Trnka, Franziska, et al.
Publicado: (2021)

Photochemical Internalization of Gemcitabine Is Safe and Effective in Locally Advanced Inoperable Cholangiocarcinoma
por: Trojan, Jörg, et al.
Publicado: (2022)

Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination
por: Haug, Markus, et al.
Publicado: (2018)

Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers
por: Otterhaug, Tone, et al.
Publicado: (2021)

The Potential Role of Lysosomal Sequestration in Sunitinib Resistance of Renal Cell Cancer
por: Azijli, Kaamar, et al.
Publicado: (2015)

The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
por: Lund, Kaja, et al.
Publicado: (2014)

Sequestered Bowel In A Atresia
por: Ijaz, Lubna
Publicado: (2012)

Sequestered gravity in gauge mediation
por: Antoniadis, Ignatios, et al.
Publicado: (2016)

The challenges of sequestering terrestrial carbon
por: Peñuelas, Josep
Publicado: (2022)

Path Following, Obstacle Detection and Obstacle Avoidance for Thrusted Underwater Snake Robots
por: Kelasidi, Eleni, et al.
Publicado: (2019)

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
por: Mamais, Adamantios, et al.
Publicado: (2021)

An étude on global vacuum energy sequester
por: D'Amico, Guido, et al.
Publicado: (2017)

Associations of red and processed meat intake with screen-detected colorectal lesions
por: Kværner, Ane Sørlie, et al.
Publicado: (2023)

Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
por: Mamais, Adamantios, et al.
Publicado: (2022)

(177)Lu-DOTA-HH1, a Novel Anti-CD37 Radio-Immunoconjugate: A Study of Toxicity in Nude Mice
por: Repetto-Llamazares, Ada H. V., et al.
Publicado: (2014)

THE PHOTOCHEMICAL REACTION IN PHOTOSYNTHESIS
por: Emerson, Robert, et al.
Publicado: (1932)

Photochemical Functionalization of Helicenes
por: Jakubec, Martin, et al.
Publicado: (2019)

MAF1 Sequesters Mitochondria for Toxoplasma gondii
por: Sedwick, Caitlin
Publicado: (2014)

Compensation, crosstalk and sequestering: The currency of checkpoints in cancer
por: Kaufmann, William K., et al.
Publicado: (2013)

Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification
por: Chen, Chun-Han, et al.
Publicado: (2017)

Deployable micro-traps to sequester motile bacteria
por: Di Giacomo, Raffaele, et al.
Publicado: (2017)

Aggregated NETs Sequester and Detoxify Extracellular Histones
por: Knopf, Jasmin, et al.
Publicado: (2019)

Scattering by obstacles
por: Ramm, A G
Publicado: (1986)

Overcoming Obstacles
por: Braile, Domingo M.
Publicado: (2015)

Splice variants of lysosome-associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells
por: Nishikawa, Ryoma, et al.
Publicado: (2020)

Overview obstacle maps for obstacle‐aware navigation of autonomous drones
por: Pestana, Jesús, et al.
Publicado: (2019)

Tree of sorrow = (Arbolucu, te sequeste) : for four part mixed chorus, SATB
por: Chávez, Carlos, 1899-1978
Publicado: (1949)

Photochemical degradation of di- and octachlorodibenzofuran.
por: Hutzinger, O, et al.
Publicado: (1973)

Cannot write session to /tmp/vufind_sessions/sess_usk9lerambf8535jk1kep2n2pc