Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

Identification of predictive biomarkers for targeted therapies requires information on drug exposure at the target site as well as its effect on the signaling context of a tumor. To obtain more insight in the clinical mechanism of action of protein kinase inhibitors (PKIs), we studied tumor drug con...

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Detalles Bibliográficos
Autores principales: Labots, Mariette, Pham, Thang V., Honeywell, Richard J., Knol, Jaco C., Beekhof, Robin, de Goeij-de Haas, Richard, Dekker, Henk, Neerincx, Maarten, Piersma, Sander R., van der Mijn, Johannes C., van der Peet, Donald L., Meijerink, Martijn R., Peters, Godefridus J., van Grieken, Nicole C.T., Jiménez, Connie R., Verheul, Henk M.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072422/
https://www.ncbi.nlm.nih.gov/pubmed/32024067
http://dx.doi.org/10.3390/cancers12020330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072422/
https://www.ncbi.nlm.nih.gov/pubmed/32024067
http://dx.doi.org/10.3390/cancers12020330

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