BGN/TLR4/NF-κB Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells

Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-κB pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not...

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Detalles Bibliográficos
Autores principales: Huang, Hsiang-Chi, Cai, Bi-He, Suen, Ching-Shu, Lee, Hsueh-Yi, Hwang, Ming-Jing, Liu, Fu-Tong, Kannagi, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072454/
https://www.ncbi.nlm.nih.gov/pubmed/32050430
http://dx.doi.org/10.3390/cells9020397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072454/
https://www.ncbi.nlm.nih.gov/pubmed/32050430
http://dx.doi.org/10.3390/cells9020397

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