Complex Mitochondrial Dysfunction Induced by TPP(+)-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, 10-((2,5-dihydroxybenzoyl)oxy)decyl) triphenylphosphonium bromide (GA-TPP(+)C(10)),...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuentes-Retamal, Sebastián, Sandoval-Acuña, Cristian, Peredo-Silva, Liliana, Guzmán-Rivera, Daniela, Pavani, Mario, Torrealba, Natalia, Truksa, Jaroslav, Castro-Castillo, Vicente, Catalán, Mabel, Kemmerling, Ulrike, Urra, Félix A., Ferreira, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072465/
https://www.ncbi.nlm.nih.gov/pubmed/32053908
http://dx.doi.org/10.3390/cells9020407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072465/
https://www.ncbi.nlm.nih.gov/pubmed/32053908
http://dx.doi.org/10.3390/cells9020407

Ejemplares similares